Human Pharmacokinetics of Iodixanol
| Autor: | K Langseth-Manrique, M. G. Svaland, E Andrew, T Haider, P A Hals |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Time Factors Metabolic Clearance Rate Contrast Media Renal function Urine Pharmacology Excretion Feces Pharmacokinetics Triiodobenzoic Acids Extracellular fluid medicine Humans Radiology Nuclear Medicine and imaging Biotransformation Edetic Acid Volume of distribution Dose-Response Relationship Drug Chemistry General Medicine Iodixanol Chromium Radioisotopes Renal physiology Injections Intravenous Glomerular Filtration Rate medicine.drug |
| Zdroj: | Investigative Radiology. 27:130-133 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/00004424-199202000-00007 |
| Popis: | The pharmacokinetic properties of the x-ray contrast medium, iodixanol, a new nonionic dimer, were investigated in a phase I study including 40 healthy male volunteers. Iodixanol (300 mg I/mL) was administered intravenously (i.v.) at four dose levels--0.3, 0.6, 0.9, and 1.2 g iodine (I)/kg body weight--and saline was given as a control. 51Cr-EDTA was given concomitantly with iodixanol at all dose levels to study renal excretion of iodixanol. Mean half-lives were 26 and 131 minutes in the distribution and elimination phase, respectively. Apparent volume of distribution was 0.28 1/kg body weight, indicating distribution to extracellular fluid only. Within 24 hours after injection, 97% of the dose was excreted unmetabolized in the urine via glomerular filtration. The excretion in feces was 1.2% of the dose. The parameters calculated were independent of the given dose. The pharmacokinetics of iodixanol are comparable with those reported for other intravascular contrast media. |
| Databáze: | OpenAIRE |
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