| Autor: |
Yevgenia, Rosenblum, Inbal, Maidan, Orly, Goldstein, Mali, Gana-Weisz, Avi, Orr-Urtreger, Noa, Bregman, Nir, Giladi, Anat, Mirelman, Tamara, Shiner |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical Neurophysiology. 143:14-20 |
| ISSN: |
1388-2457 |
| DOI: |
10.1016/j.clinph.2022.08.011 |
| Popis: |
To compare event-related oscillations in patients with dementia with Lewy bodies (DLB) who are carriers and non-carriers of glucocerebrosidase (GBA) mutations.EEG was recorded during a visual oddball task in eight Ashkenazi Jewish DLB patients with the N370S mutation in theGBAgene (GBA-DLB) and eleven DLB non-carriers. The time-frequency power and inter-trial phase clustering were calculated from the Morlet wavelet convolution for the midline electrodes.Task performance and cognitive assessments were comparable between groups. While the within-non-GBA-DLB group analysis revealed delta-band power synchronization relative to the baseline (p = 0.01, Cohen's d = 1.0), the within-GBA-DLB-group analysis detected no event-related changes in power. Both groups showed an increase relative to the baseline in the delta and theta bands inter-trial phase clustering (all p 0.03, d 1.3). The between-group analysis revealed that event-related power - but not clustering - was lower in GBA-DLB compared to non-carriers in the delta band at Fz and Cz (p = 0.04, d = -0.9).GBA-DLB patients showed decreased delta-band power compared to non-carriers despite the similar cognitive performance, whereas inter-trial phase clustering was comparable in both groups.Preserved inter-trial phase clustering possibly compensates for the impaired power by eliciting the appropriate functional configuration needed for stimulus processing and task performance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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