Ubiquitination-Dependent Regulation of Signaling Receptors in Cancer

Autor:	Wei Chun HuangFu, Serge Y. Fuchs
Rok vydání:	2010
Předmět:	Cancer Research Cell signaling biology Kinase Ubiquitin ligase Cell biology Cell surface receptor Genetics Extracellular biology.protein Monographs Signal transduction Receptor Autocrine signalling
Zdroj:	Genes & Cancer. 1:725-734
ISSN:	1947-6027 1947-6019
Popis:	Ubiquitination of signaling cell surface receptors is a key mechanism regulating the availability of these receptors to interact with extracellular ligands. Accordingly, this regulation determines the sensitivity of cells to the humoral and locally secreted regulators of cell function, proliferation, and viability. Alterations in receptor ubiquitination and degradation are often encountered in cancers. Malignant cells utilize modified ubiquitination of signaling receptors to augment or attenuate signaling pathways on the basis of whether the outcome of this signaling is conducive or not for tumor growth and survival. These mechanisms as well as their significance for the treatment of human cancers are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf93f1592ebeac29004b7bb31481bf26 https://doi.org/10.1177/1947601910382901 Zobrazit plný text záznamu