Relationship between vascular stiffness and stress myocardial perfusion imaging in asymptomatic patients with diabetes
| Autor: | Bernies van der Hiel, Imad Al Younis, Alberto M. Pereira, J. Wouter Jukema, Joanne D. Schuijf, Eelco J.P. de Koning, Arthur J.H.A. Scholte, Jeroen J. Bax, Ton J. Rabelink, Cornelis J. Roos, Roxana Djaberi, Jan W. A. Smit |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Vascular stiffness Asymptomatic Coronary artery disease Myocardial perfusion imaging Diabetes mellitus Stress Physiological Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Pulse wave velocity Mechanical Phenomena Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Biomechanical Phenomena SSS Radiology Nuclear Medicine and imaging Asymptomatic Diseases Cardiology Blood Vessels Original Article Female medicine.symptom business Perfusion |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging European Journal of Nuclear Medicine and Molecular Imaging, 38(11), 2050-2057 |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | Purpose Vascular stiffness may potentially be used as a screening tool to identify asymptomatic patients with diabetes with abnormal myocardial perfusion. The purpose of this study was therefore to determine the association between vascular stiffness, measured in term of pulse wave velocity (PWV) and augmentation index (AIx), and abnormal myocardial perfusion imaging (MPI) in asymptomatic patients with diabetes. Methods Prospectively, 160 asymptomatic patients with diabetes (mean age 51 years, 87 men) underwent MPI with adenosine stress. The summed stress score (SSS) was determined in each patient according to a 17-segment and five-point score. Abnormal MPI (SSS ≥3) was classified as moderate (SSS 3–7) or severe (SSS ≥8) MPI defects. Using applanation tonometry, the carotid–femoral PWV and the radial AIx corrected to 75 beats per minute were determined noninvasively. Results MPI was abnormal in 61 patients (38%), with severe MPI defects in 22 patients (14%). Mean PWV increased with deteriorating MPI from 8.4 ± 2.2 m/s in normal MPI to 9.0 ± 2.2 m/s in moderate MPI defects (p = 0.11) and to 11.1 ± 2.5 m/s in severe MPI defects (p |
| Databáze: | OpenAIRE |
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