Investigation of the Transfer of Septum Microbial Contamination by Hypodermic Needles

Autor:	T. Eaton, J Cox, L Ramscar, William Whyte
Rok vydání:	2020
Předmět:	fluids and secretions integumentary system business.industry Environmental chemistry parasitic diseases virus diseases Medicine Microbial contamination business
Zdroj:	EJPPS EUROPEAN JOURNAL OF PARENTERAL AND PHARMACEUTICAL SCIENCES.
ISSN:	2633-6588 0964-4679 1740-6277
DOI:	10.37521/ejpps/2501
Popis:	The likelihood of the transfer of microbial contamination from the surface of a vial septum into the vial liquid, by penetration of a hypodermic syringe needle, has been investigated. Experimental work was carried out with vials containing sterile microbial growth media and the use of needles of three different diameters. Three different concentrations of microbes on the surface of the vial septum (10, 100, and 1000) were used. Microbial contamination that was transferred into the growth media was determined by incubation of the vials following penetration of the septum by the needles. Contamination was detected in 87% of all the vials tested, and was generally found to increase as the concentration of septum challenge organisms and needle diameter increased. Key words: Septum seals, hypodermic needles, multi-use vials, microbial contamination
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf934881168bbde79f19e519a0b28cc4 https://doi.org/10.37521/ejpps/2501 Zobrazit plný text záznamu