| Autor: |
Chen, RY, Via, LE, Dodd, LE, Walzl, G, Malherbe, ST, Loxton, AG, Dawson, R, Wilkinson, RJ, Thienemann, F, Tameris, M, Hatherill, M, Diacon, AH, Liu, X, Xing, J, Jin, X, Ma, Z, Pan, S, Zhang, G, Gao, Q, Jiang, Q, Zhu, H, Liang, L, Duan, H, Song, T, Alland, D, Tartakovsky, M, Rosenthal, A, Whalen, C, Duvenhage, M, Cai, Y, Goldfeder, LC, Arora, K, Smith, B, Winter, J, Barry Iii, CE, Predict TB Study Group |
| Přispěvatelé: |
European and Developing Countries Clinical Trials Partnership |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.25418/crick.15179703.v1 |
| Popis: |
Background: By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months, maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have failed, with 4-month arms consistently having relapse rates of 15-20%. One trial shortened treatment only among those without baseline cavity on chest x-ray and whose month 2 sputum culture converted to negative. The 4-month arm relapse rate decreased to 7% but was still significantly worse than the 6-month arm (1.6%, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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