Budesonide Reverses Lung Hyperinflation in Childhood Asthma: a Controlled Study

Autor:	Nuno Neuparth, Teresa Gamboa, Cláudia Margarida Brito Pereira, J Rusado Pinto, António Bensabat Rendas
Jazyk:	angličtina
Rok vydání:	1999
Předmět:	Budesonide Childhood asthma business.industry Criança medicine.disease Placebo Lung hyperinflation Crossover study Pathology and Forensic Medicine Physiology (medical) Anesthesia HDE ALER Broncopatias medicine Plethysmograph Budesonida Lung volumes business Asma Asthma medicine.drug
Zdroj:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP
Popis:	Budesonide (800 mg bid, for 2 months) was administered to 12 asthmatic children (mean age, 11.293.3 years) with lung hyperinflation (TGV]130% predicted and:or RV]140% predicted) in a randomised, placebo controlled, double blind, crossover study. Body plethysmography (panting frequency controlled at 1·s 1) was performed at the beginning, 2 months afterwards (before crossover) and at the end of the study. Budesonide significantly reduced TGV (2.3590.90 l BTPS or 126924% predicted) compared with placebo (2.5491.08 l BTPS, P 0.014 or 140921% predicted, PB0.05). In addition, budesonide significantly increased mean specific conductance (0.0690.02 cm H2O 1 l s 1 to 0.0790.01 cm H2O 1 l s 1, PB0.05). It was concluded that budesonide reduced lung hyperinflation most likely by decreasing airway inflammation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf90e6dcee9636abec67087be3f8f093 https://hdl.handle.net/10400.17/1699 Zobrazit plný text záznamu