Association of Helicobacter pylori Infection With Cardiovascular and Cerebrovascular Disease in Diabetic Patients

Autor: H. de la Calle, A. L. San Roman, Boixeda D, Rafael Cantón, Rocío Aller, D.A. de Luis, M Lahera
Rok vydání: 1998
Předmět:
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Population
Diabetic angiopathy
Gastroenterology
Helicobacter Infections
Diabetes Complications
Diabetic Neuropathies
Risk Factors
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Internal Medicine
medicine
Humans
Diabetic Nephropathies
Risk factor
education
Peripheral Vascular Diseases
Advanced and Specialized Nursing
education.field_of_study
Diabetic Retinopathy
Helicobacter pylori
biology
business.industry
Case-control study
Odds ratio
Diabetic retinopathy
Middle Aged
medicine.disease
biology.organism_classification
Cerebrovascular Disorders
Cross-Sectional Studies
Diabetes Mellitus
Type 1
Diabetes Mellitus
Type 2
Cardiovascular Diseases
Case-Control Studies
Immunology
Female
business
Biomarkers
Diabetic Angiopathies
Zdroj: Diabetes Care. 21:1129-1132
ISSN: 1935-5548
0149-5992
DOI: 10.2337/diacare.21.7.1129
Popis: OBJECTIVE Infection by Helicobacter pylori has been epidemiologically linked to some extradigestive conditions, including ischemic heart disease. Diabetic patients are an at-risk population for cardiovascular and thrombo-occlusive cerebral disease. The aim of the study was to examine a possible relationship between H. pylori infection and cardiovascular or cerebrovascular disease in diabetic patients. RESEARCH DESIGN AND METHODS This was a cross-sectional case-control study with 127 diabetic patients (both IDDM and NIDDM). Special emphasis was placed on the detection of clinical macro- and microvascular complications, cardiovascular risk factors, acute phase reactants, and serological markers of increased cardiovascular disease risk. H. pylori infection was assessed through the determination of specific Ig-G titers, measured by a commercial enzyme-linked immunosorbent assay. RESULTS Coronary heart disease was more prevalent in diabetic patients with than without H. pylori (odds ratio [OR] 4.07; 95% Cl 1.21–13.6; P < 0.05). A history of thrombo-occlusive cerebral disease was also more frequent in H. pylori–positive diabetic patients (OR 4.8; 95% CI 1.24–18.51; P < 0.05). Other complications such as peripheral arteriopathy, advanced nephropathy, neuropathy, or retinopathy were no differently distributed according to serological status. Alterations in the levels of the following acute-phase reactants and blood chemistry determinations were significantly more profound in H. pylori–positive diabetic patients: high fibrinogen (P < 0.05), high erythrocyte sedimentation rate (P < 0.001), high triglycerides (P < 0.001), and low HDL cholesterol (P < 0.001). These values were also more deeply altered in H. pylori–positive diabetic patients with a history of coronary heart disease, thrombo-occlusive cerebral disease, or both, when compared with H. pylori–positive diabetic patients without those complications. CONCLUSIONS Our data indicate a possible association of H. pylori infection and the development of coronary heart disease, thrombo-occlusive cerebral disease, or both, in diabetic patients. The importance of this link is highlighted by the possibility of an effective intervention against H. pylori infection.
Databáze: OpenAIRE
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