An evaluation of glycated haemoglobin eluting in zone 10 on capillary zone electrophoresis
Autor: | Beverley M. Pullon |
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Rok vydání: | 2019 |
Předmět: |
Thesaurus (information retrieval)
zone 10 peaks Chromatography Chemistry hba1c Biochemistry (medical) Clinical Biochemistry 03 medical and health sciences 0302 clinical medicine Capillary electrophoresis capillary zone electrophoresis 030220 oncology & carcinogenesis Medical technology glycated haemoglobin Discrete Mathematics and Combinatorics R855-855.5 Glycated haemoglobin 030215 immunology |
Zdroj: | Journal of Laboratory Medicine, Vol 44, Iss 1, Pp 55-58 (2020) |
ISSN: | 2567-9449 2567-9430 |
DOI: | 10.1515/labmed-2019-0136 |
Popis: | This is the first report of glycated haemoglobin (Hb) eluting in zone 10 on capillary zone electrophoresis (CZE). In an index case, the aberrant peak was picked up during routine haemoglobinopathy testing using CZE. Mass spectrometry (MS) revealed this aberrant peak to be glycated Hb. Prompted by this initial case, a study was undertaken and the results showed that there was a strong positive linear relationship (R2 = 0.774; ρ = 0.88) between the level of glycated Hb peak eluting in zone 10 and the HbA1c value. Furthermore, all samples with an HbA1c of 54 mmol/mol or greater had an HbA1c peak eluting in zone 10. |
Databáze: | OpenAIRE |
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