and variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients
| Autor: | Fernanda Viviane Mariano, João Maurício Carrasco Altemani, Guilherme Nogueira, Patricia Moriel, Júlia Coelho França Quintanilha, Albina Altemani, Carmen Silvia Passos Lima, Tathiane Regine Penna Lima, Marília Berlofa Visacri, Celso Dario Ramos, Leisa Lopes-Aguiar, Ericka Francislaine Dias Costa, Luciane Calonga, Carlos Takahiro Chone, Eder de Carvalho Pincinato |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cisplatin Oncology medicine.medical_specialty business.industry medicine.medical_treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens General Medicine medicine.disease Response to treatment Head and neck squamous-cell carcinoma Fas ligand Radiation therapy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cell killing 030220 oncology & carcinogenesis Internal medicine medicine In patient business Adverse effect RC254-282 medicine.drug |
| Zdroj: | Tumor Biology, Vol 42 (2020) |
| ISSN: | 1423-0380 |
| Popis: | Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects. The aim of this prospective study was to evaluate the roles of TP53 c.215G > C, FAS c.-671A > G, FAS c.-1378G > A, FASL c.-844 C > T, CASP3 c.-1191A > G, and CASP3 c.-182-247G > T single nucleotide variants in toxicity, response rate, and survival of cisplatin chemoradiation-treated head and neck squamous cell carcinoma patients. Genomic DNA was analyzed by polymerase chain reaction for genotyping. Differences between groups of patients were analyzed by chi-square test or Fisher’s exact test, multiple logistic regression analysis, and Cox hazards model. One hundred nine patients with head and neck squamous cell carcinoma were enrolled in study. All patients were smokers and/or alcoholics. Patients with FAS c.-671GG genotype, FAS c.-671AG or GG genotype, and FASL c.-844CC genotype had 5.52 (95% confidence interval (CI): 1.42–21.43), 4.03 (95% CI: 1.51–10.79), and 5.77 (95% CI: 1.23–27.04) more chances of presenting chemoradiation-related anemia of grades 2–4, lymphopenia of grade 3 or 4, and ototoxicity of all grades, respectively, than those with the remaining genotypes. FAS c.-671GG genotype was also seen as an independent predictor of shorter event-free survival (hazard ratio (HR): 2.05; P = 0.007) and overall survival (HR: 1.83; P = 0.02) in our head and neck squamous cell carcinoma patients. These findings present, for the first time, preliminary evidence that inherited abnormalities in apoptosis pathway, related to FAS c.-671A > G and FASL c.-844 C > T single nucleotide variants, can alter toxicity and survival of tobacco- and alcohol-related head and neck squamous cell carcinoma patients homogeneously treated with cisplatin chemoradiation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|