Medication use and kidney cancer risk: A population-based study
| Autor: | Erin M. Macdonald, Antonio Finelli, David N. Juurlink, Madhur Nayan, Robert J. Hamilton, Girish S. Kulkarni, Peter C. Austin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Prescription Drugs Population Cumulative Exposure 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Carcinoma Humans 030212 general & internal medicine Medical prescription Intensive care medicine education Aged Aged 80 and over Ontario education.field_of_study Medication use business.industry Incidence Pharmacoepidemiology medicine.disease Kidney Neoplasms Population based study Logistic Models Oncology Case-Control Studies 030220 oncology & carcinogenesis Female business Kidney cancer |
| Zdroj: | European Journal of Cancer. 83:203-210 |
| ISSN: | 0959-8049 |
| Popis: | Exposure to commonly prescribed medications may be associated with cancer risk. However, there is limited data in kidney cancer. Furthermore, methods of classifying cumulative medication exposure in previous studies may be prone to bias.We conducted a population-based case-control study of 10,377 incident kidney cancer cases aged ≥66 years matched with 35,939 controls on age, sex, history of hypertension, comorbidity score, and geographic location. Cumulative exposure to commonly prescribed medications hypothesised to modulate cancer risk was obtained using prescription claims data. We modelled exposure in four different fashions: (1) as continuous exposures using (a) fractional polynomials (which allow for a non-linear relationship between an exposure and outcome) or (b) assuming linear relationships; and 2) as dichotomous exposures denoting (a) ≥3 years versus 3 years exposure; or (b) "ever" versus "never" exposure. We used conditional logistic regression to estimate the association of medication exposure on incident kidney cancer.The directions of association were relatively consistent across analyses; however, the magnitudes were sensitive to the method of analysis. When utilising fractional polynomials, increasing cumulative exposure to acetylsalicylic acid, selective serotonin reuptake inhibitors, and proton-pump inhibitors was associated with significantly reduced risk of kidney cancer, while increasing exposure to antihypertensive drugs was associated with significantly increased risk.Our study provides impetus to further explore the effect of commonly prescribed medications on carcinogenesis to identify modifiable pharmacological interventions to reduce the risk of kidney cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect