High Frequency of Herpesvirus-Specific Clonotypes in the Human T Cell Repertoire Can Remain Stable over Decades with Minimal Turnover
| Autor: | Scott R. Burrows, Melissa J Rist, Michelle A Neller, John J. Miles, Jacqueline M. Burrows |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Time Factors T-Lymphocytes T cell Molecular Sequence Data Immunology Receptors Antigen T-Cell Blood Donors Biology medicine.disease_cause Microbiology Viral infection Virus Virology medicine Humans Amino Acid Sequence Aged T cell repertoire T-cell receptor Genetic Variation Cytomegalovirus Sequence Analysis DNA Middle Aged medicine.anatomical_structure Epstein barr Insect Science Healthy individuals Receptors Virus Pathogenesis and Immunity |
| Zdroj: | Journal of Virology. 87:697-700 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little. |
| Databáze: | OpenAIRE |
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