Effect of recombinant interleukin-5, interleukin-3, and eotaxin on apoptosis in eosinophilic granulocytes
| Autor: | Grigor'eva Es, Yu. V. Kolobovnikova, N. Yu. Chasovskikh, Tkachenko Sb, T. T. Radzivil, E. N. Knutareva, E. V. Suvorova, V. V. Novitskii, Larisa Litvinova, N. V. Ryazantseva, O. B. Zhukova |
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| Rok vydání: | 2008 |
| Předmět: |
Eotaxin
Adult Male Adolescent Apoptosis Recombinant Interleukin General Biochemistry Genetics and Molecular Biology law.invention immune system diseases law hemic and lymphatic diseases Eosinophilic Eosinophilia medicine Humans Cells Cultured Interleukin 3 business.industry Lymphoma Non-Hodgkin General Medicine respiratory system Middle Aged In vitro Recombinant Proteins Eosinophils Case-Control Studies Chemokines CC Immunology Recombinant DNA Female Interleukin-3 medicine.symptom Interleukin-5 business |
| Zdroj: | Bulletin of experimental biology and medicine. 143(4) |
| ISSN: | 0007-4888 |
| Popis: | We studied in vitro effects of recombinant interleukin-5, interleukin-3, and eotaxin on programmed death of eosinophils from healthy donors and patients with non-Hodgkin’s lymphomas associated with severe blood eosinophilia. Interleukin-5 and eotaxin produced the most potent antiapoptotic effect on eosinophils from healthy donors. In patients with non-Hodgkin’s lymphomas, spontaneous apoptosis in eosinophilic leukocytes was low and remained unchanged during incubation with recombinant proteins. |
| Databáze: | OpenAIRE |
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