Exercise-Induced Hyperhomocysteinemia Is Not Related to Oxidative Damage or Impaired Vascular Function in Amateur Middle-Aged Runners under Controlled Nutritional Intake
| Autor: | David de Gonzalo-Calvo, Eduardo Iglesias-Gutiérrez, Cristina Tomás-Zapico, Ana Montero-Bravo, Antonio González-Medina, Natalia Úbeda, Judit Joglar, Ángela García-González, Manuel Fernández-Sanjurjo, Ángel Enrique Díaz-Martínez, Benjamín Fernández-García |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Hyperhomocysteinemia Homocysteine Oxidative phosphorylation medicine.disease_cause Article Running long-term acute exercise chemistry.chemical_compound Basal (phylogenetics) endothelial function Internal medicine medicine Humans oxidative stress TX341-641 Endothelial dysfunction Nutrition and Dietetics business.industry Nutrition. Foods and food supply Glutathione homocysteine Middle Aged medicine.disease Diet Endocrinology chemistry Endothelium Vascular business Vascular function Oxidative stress Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 3033, p 3033 (2021) Scopus Nutrients Volume 13 Issue 9 RUO. Repositorio Institucional de la Universidad de Oviedo instname |
| ISSN: | 2072-6643 |
| Popis: | To determine the influence of different doses of maximal acute exercise on the kinetics of plasma homocysteine (tHcy) and its relationship with oxidative status and vascular function, nine recreational runners completed a 10 km race (10K) and a marathon (M). Blood samples were collected before (Basal), immediately post-exercise (Post0), and after 24 h (Post24). Nutritional intake was controlled at each sample point. A significant increase in tHcy was observed after both races, higher after M. Basal levels were recovered at Post24 after 10K, but remained elevated at Post 24 for M. A significant decrease in GSH/GSSG ratio was observed in Post0, especially marked after M. Furthermore, this increase in pro-oxidant status remained at Post24 only after M. Other oxidative status markers failed to confirm this exercise-induced pro-oxidant status except glutathione peroxidase activity that was lower in Post24 compared to Basal in 10K and in Post0 and Post24 in M. No statistical correlation was found between oxidative markers and tHcy. No significant changes were observed in the concentration of endothelial cell adhesion molecules (VCAM-1 and E-Selectin) and VEGF. In conclusion, tHcy increases in an exercise–dose–response fashion but is not related to endothelial dysfunction mediated by oxidative stress mechanisms. |
| Databáze: | OpenAIRE |
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