Advances in the Study of Antitumour Immunotherapy for Newcastle Disease Virus

Autor: Qiuxing Meng, Yongxiang Zhao, Jian He, Liping Zhong
Rok vydání: 2021
Předmět:
medicine.medical_treatment
viruses
animal diseases
Review
Monocytes
Immune tolerance
0302 clinical medicine
Genetic engineering technology
Neoplasms
Tumor Microenvironment
Medicine
Oncolytic Virotherapy
Vaccines
Synthetic
biology
General Medicine
Combined Modality Therapy
Up-Regulation
Killer Cells
Natural
embryonic structures
030211 gastroenterology & hepatology
Immunotherapy
Genetic Engineering
animal structures
Newcastle disease virus
Vaccines
Attenuated
Newcastle disease
Cancer Vaccines
Virus
03 medical and health sciences
Immune checkpoint inhibitors
Immune system
Downregulation and upregulation
Cell Line
Tumor
Animals
Humans
business.industry
Macrophages
Viral Vaccines
Dendritic Cells
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
Immune Checkpoint Proteins
Immune checkpoint
Blockade
Disease Models
Animal
Drug Resistance
Neoplasm
Cancer research
Tumor Escape
Recombinant NDV
Tumour
business
Zdroj: International Journal of Medical Sciences
ISSN: 1449-1907
Popis: This article reviews the preclinical research, clinical application and development of Newcastle disease virus (NDV) in the field of cancer therapy. Based on the distinctive antitumour properties of NDV and its positive interaction with the patient's immune system, this biologic could be considered a major breakthrough in cancer treatment. On one hand, NDV infection creates an inflammatory environment in the tumour microenvironment, which can directly activate NK cells, monocytes, macrophages and dendritic cells and promote the recruitment of immune cells. On the other hand, NDV can induce the upregulation of immune checkpoint molecules, which may break immune tolerance and immune checkpoint blockade resistance. In fact, clinical data have shown that NDV combined with immune checkpoint blockade can effectively enhance the antitumour response, leading to the regression of local tumours and distant tumours when injected, and this effect is further enhanced by targeted manipulation and modification of the NDV genome. At present, recombinant NDV and recombinant NDV combined with immune checkpoint blockers have entered different stages of clinical trials. Based on these studies, further research on NDV is warranted.
Databáze: OpenAIRE
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