HEMOGLOBIN C TRAIT PRESENTING WITH BILATERAL CENTRAL RETINAL VEIN OCCLUSION
| Autor: | Riley N Sanders, Sami H. Uwaydat, Manojna Konda, Adam J Neuhouser |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
medicine.medical_specialty
Hemoglobin electrophoresis Visual acuity medicine.diagnostic_test business.industry Microangiopathy General Medicine medicine.disease Fluorescein angiography eye diseases Hemoglobin C Ophthalmology Central retinal vein occlusion medicine Epiretinal membrane medicine.symptom business Macular edema |
| Zdroj: | RETINAL Cases & Brief Reports. 17:44-46 |
| ISSN: | 1935-1089 |
| DOI: | 10.1097/icb.0000000000001097 |
| Popis: | Purpose To report a case of bilateral sequential, CRVO in a man with newly diagnosed hemoglobin C trait. Methods A 67-year-old man presented with a one-month history of declining visual acuity. He was diagnosed with left CRVO. Bilateral temporal retinal ischemia and arteriovenous anastomoses on fluorescein angiography suggestive of sickle cell retinopathy prompted a systemic work-up. Hemoglobin electrophoresis revealed an underlying hemoglobin C trait. Six-months after his initial presentation, the patient developed symptomatic right CRVO. Results The initial left CRVO was complicated by optic disc swelling and macular edema. Intravitreal anti-angiogenic therapy was initiated and the macular edema resolved. The left eye subsequently developed an epiretinal membrane which was surgically removed. Macular edema in the right eye also resolved after intravitreal anti-angiogenic therapy. Conclusion This is the first reported case of bilateral CRVO in a case of hemoglobin C trait. It is possible that erythrocyte inflexibility, caused by hemoglobin C induced dehydration and crystallization, acted concomitantly with hypertension to produce occlusive microangiopathy. This case highlights the need for further investigation in patients presenting with central retinal vein occlusion, especially when bilateral, or when retinal angiography reveals bilateral pathology. |
| Databáze: | OpenAIRE |
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