Association between IL-18 and IL-6 gene polymorphisms and the risk of T1D in Egyptian children
| Autor: | Mohamed H. El-Hefnawy, Mahmoud E. Gadalla, Mohamed El-Shahat, Nehal E. Abdel-Hakem, Yasser B.M. Ali, Hend El-Sayed El-Gahel |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system diseases business.industry Endocrinology Diabetes and Metabolism Haplotype 030209 endocrinology & metabolism Single-nucleotide polymorphism Promoter 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology chemistry Polymorphism (computer science) Internal medicine Genotype Internal Medicine Medicine Interleukin 18 Glycated hemoglobin Allele business Research Article |
| Zdroj: | J Diabetes Metab Disord |
| Popis: | PURPOSE: To test the involvement between IL-18 and IL-6 genetic polymorphisms and susceptibility to Type 1 diabetes (T1D). METHODS: Single nucleotide polymorphisms (SNPs) at positions −607A/C and − 137G/C in IL-18 promoter region were examined by sequence specific primers-polymerase chain reaction (SSP-PCR) and position -174G/C in promoter region of IL-6 gene which analyzed by Mutagenically Separated PCR (MS-PCR) in 104 T1D participants and 114 controls. RESULTS: IL-18 -137GC and -137CC genotypes and -137C allele were significantly decreased in T1D subjects (P |
| Databáze: | OpenAIRE |
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