Elastolytic Activity of Human Monocytes from Synovial Fluid and Blood of Patients with Arthritis. Relations to Levels of Interleukin 6 and Soluble Interleukin 2 Receptor
| Autor: | H. S. Jensen, Klaus Bendtzen, B. S. Thomsen, Niels Tvede, P. B. Pedersen, H. H. Mogensen, M. Diamant, M. B. Hansen |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Interleukin 2 medicine.medical_specialty medicine.medical_treatment Immunology Arthritis Monocytes Arthritis Rheumatoid Interferon-gamma Rheumatology Internal medicine Osteoarthritis Synovial Fluid Humans Immunology and Allergy Medicine Synovial fluid Interleukin 6 Receptor Aged biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Monocyte Receptors Interleukin-2 General Medicine Middle Aged Elastic Tissue medicine.disease Cytokine Endocrinology medicine.anatomical_structure Rheumatoid arthritis biology.protein business medicine.drug |
| Zdroj: | Scandinavian Journal of Rheumatology. 20:83-90 |
| ISSN: | 1502-7732 0300-9742 |
| Popis: | Synovial fluid (SF) and blood from 24 patients with non-traumatic, sterile hydarthron were examined for monocyte elastolysis (MøE) and for levels of interleukin 6 (IL-6) and of soluble interleukin 2 receptor (sIL-2R). Six patients had osteoarthrosis (OA) and 18 patients had inflammatory hydarthron (IH), 10 of whom had rheumatoid arthritis (RA). Blood MøE was lower in OA than in IH, both measured as basal MøE activity and after in vitro stimulation with immune complexes and phorbol myristate acetate (PMA). SF MøE was higher than MøE in blood (p less than 0.01). This increase in SF MøE could be mimicked in vitro by prestimulation of blood Mø with low levels of IC. SF IL-6 and sIL-2R were also elevated (p less than 0.01). All three parameters correlated to the degree of joint inflammation evaluated by SF leucocyte level, complement activation, blood C Reactive Protein, and to the clinical evaluation of the joint. The increase in SF MøE, IL-6 and sIL-2R in patients with IH, points to a stimulation of Mø and lymphocytes in the joint. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|