Attentive and preattentive processing in narcolepsy as revealed by event-related potentials (ERPs)
| Autor: | Angela Naumann, Jürgen Bierbrauer, Horst Przuntek, Irene Daum |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Cataplexy Rapid eye movement sleep Prefrontal Cortex Mismatch negativity Excessive daytime sleepiness Event-related potential Reaction Time medicine Humans Attention Prefrontal cortex Aged Narcolepsy Sleep disorder General Neuroscience Auditory Perceptual Disorders Electroencephalography Middle Aged medicine.disease Event-Related Potentials P300 Acoustic Stimulation Attention Deficit Disorder with Hyperactivity Female medicine.symptom Psychology Neuroscience |
| Zdroj: | Neuroreport. 12:2807-2811 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200109170-00011 |
| Popis: | Narcolepsy is a neurological disorder, characterised by excessive daytime sleepiness, sleep attacks, cataplexy and abnormal manifestations of rapid eye movement sleep. Recent studies suggest that neuropsychological impairments in narcolepsy may include memory and attention deficits due to a monoaminergic or cholinergic transmitter dysfunction. To explore the nature of cognitive problems, the P300 and mismatch negativity (MMN) event-related potentials were investigated in narcoleptic patients and matched controls. Narcoleptics showed significantly increased P300 amplitudes relative to controls, especially at frontal recording sites. While control subjects exhibited typically larger MMN over the right than the left hemisphere, in particular at frontal and central electrodes, narcoleptics did not show this asymmetry. These results are interpreted as possible alterations in cognitive preattentive and attentive processing associated with altered functioning of the prefrontal cortex in narcolepsy. |
| Databáze: | OpenAIRE |
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