Hormonal factors associated with weight loss in patients with advanced breast cancer
| Autor: | Robert H Phillips, Martyn L Knapp, Said Al-Sheibani, Ian W F Hanham, Pamela G. Riches |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
endocrine system 030213 general clinical medicine medicine.medical_specialty Cachexia Hydrocortisone medicine.medical_treatment Clinical Biochemistry 030209 endocrinology & metabolism Breast Neoplasms Glucagon 03 medical and health sciences 0302 clinical medicine Breast cancer Weight loss Pituitary Hormones Anterior Internal medicine Diabetes mellitus Weight Loss medicine Humans Aged Neoplasm Staging Aged 80 and over business.industry Tumor Necrosis Factor-alpha Insulin Cancer General Medicine Middle Aged medicine.disease Pancreatic Hormones Endocrinology Female medicine.symptom business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Annals of clinical biochemistry. 28 |
| ISSN: | 0004-5632 |
| Popis: | SUMMARY. Fasting blood samples were collected from 83 patients with histologically proven breast cancer and analysed for plasma glucagon, serum immunoreactive tumour necrosis factor (TNFa), insulin, glucose, growth hormone, cortisol and TSH. Samples from patients with known diabetes mellitus or thyroid disease, and those on parenteral nutrition or with evidence of infection were excluded as were patients who had a history of weight loss through dieting or who were anorexic. Fasting plasma glucagon, serum cortisol and immunoreactive TNFa concentrations in patients with stage IV breast cancer who had developed weight loss were significantly higher than those in patients with stage IV disease who had not developed weight loss. There were no significant differences in the fasting serum concentrations of insulin, glucose, growth hormone and TSH between the two patient groups. The association between weight loss in stage IV breast cancer and increased concentrations of plasma glucagon, serum cortisol and TNFa suggests a possible role for these hormonal factors in the development of cancer cachexia. Additional key phrases: cancer cachexia; cachectin; glucagon; cortisol; tumour necrosis factor |
| Databáze: | OpenAIRE |
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