Relative contribution of foetal and post-natal nutritional periods on feeding regulation in adult rats
| Autor: | Patricia Parnet, Jean-Philippe Antignac, G. Le Dréan, Marie-Cécile Alexandre-Gouabau, A. Martin Agnoux |
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| Přispěvatelé: | Physiologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Centre de Recherche en Nutrition Humaine, Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Recherche Agronomique (INRA), PONAN (PoleNantais Alimentation et Nutrition) |
| Rok vydání: | 2013 |
| Předmět: |
Male
Food intake medicine.medical_specialty Aging Physiology [SDV]Life Sciences [q-bio] media_common.quotation_subject Neuropeptide Intrauterine growth restriction Adipose tissue Biology Weight Gain leptin peri-natal nutrition Rats Sprague-Dawley chemistry.chemical_compound Food Preferences Pregnancy metabolic programming Internal medicine medicine Ingestion Animals Enterostatin feeding regulation Prenatal Nutritional Physiological Phenomena media_common 2. Zero hunger Feedback Physiological Fetal Growth Retardation Leptin Appetite Feeding Behavior medicine.disease Rats high-fat diet Endocrinology chemistry Female |
| Zdroj: | Acta Physiologica Acta Physiologica, Wiley, 2014, 210 (1), pp.188-201. ⟨10.1111/apha.12163⟩ |
| ISSN: | 1748-1716 1748-1708 |
| DOI: | 10.1111/apha.12163⟩ |
| Popis: | International audience; AimThe aim of this study was to assess the contribution of both foetal and/or post-natal nutritional periods on feeding regulation in adult rats. MethodsBody weight gain, adipose tissue development, food preferences and feeding pattern under regular chow or Western diets were characterized on four experimental groups of rats: pups born from protein-restricted dams (R) and weaned by control (RC) or R dams (RR) and pups born from control dams weaned by C (CC) or R dams (CR). ResultsRats born with intrauterine growth restriction (IUGR) and fed a Western diet at adulthood appeared predisposed to body weight gain and more fat accretion, whereas CR rats, despite their preference for high-fat diet and their hyperphagia for Western diet, did not show significant increase in fat tissue. Daytime food intakes, as well as their speed of ingestion, were found modified in RC and RR. Alterations in the hypothalamic appetite regulatory mechanisms were investigated through neuropeptide expression analysis. IUGR rats showed altered expression of key elements of leptin and NPY signalling, while CR rats exhibited lesser expression of enterostatin, MC4r and HT-1Br mRNA. ConclusionAltogether, these results indicate that peri-natal nutrition has different lasting effects on feeding pattern and hypothalamic appetite regulation, depending on the time window insult. |
| Databáze: | OpenAIRE |
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