Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion
| Autor: | Joanna Segal, Mariia Yuneva, Peter A. Kreuzaler, Yulia Panina |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine Citric Acid Cycle 030209 endocrinology & metabolism Biology Article Pentose Phosphate Pathway 03 medical and health sciences Metabolic flexibility Central carbon metabolism 0302 clinical medicine Tumour metabolism Neoplasms medicine Humans Neoplasm Invasiveness lcsh:RC31-1245 Molecular Biology Cell Proliferation Flexibility (engineering) Glutaminolysis Cancer Cell Biology medicine.disease Evasion (ethics) Tumourigenesis 3. Good health Metabolic pathway Glucose 030104 developmental biology Tumor progression Anaerobic glycolysis Mutation Tumor Escape Energy Metabolism Glycolysis Neuroscience Flux (metabolism) Metabolic Networks and Pathways |
| Zdroj: | Molecular Metabolism Molecular Metabolism, Vol 33, Iss, Pp 83-101 (2020) |
| ISSN: | 2212-8778 |
| Popis: | Background: It has been known for close to a century that, on average, tumors have a metabolism that is different from those found in healthy tissues. Typically, tumors show a biosynthetic metabolism that distinguishes itself by engaging in large scale aerobic glycolysis, heightened flux through the pentose phosphate pathway, and increased glutaminolysis among other means. However, it is becoming equally clear that non tumorous tissues at times can engage in similar metabolism, while tumors show a high degree of metabolic flexibility reacting to cues, and stresses in their local environment. Scope of the review: In this review, we want to scrutinize historic and recent research on metabolism, comparing and contrasting oncogenic and physiological metabolic states. This will allow us to better define states of bona fide tumor metabolism. We will further contextualize the stress response and the metabolic evolutionary trajectory seen in tumors, and how these contribute to tumor progression. Lastly, we will analyze the implications of these characteristics with respect to therapy response. Major conclusions: In our review, we argue that there is not one single oncogenic state, but rather a diverse set of oncogenic states. These are grounded on a physiological proliferative/wound healing program but distinguish themselves due to their large scale of proliferation, mutations, and transcriptional changes in key metabolic pathways, and the adaptations to widespread stress signals within tumors. We find evidence for the necessity of metabolic flexibility and stress responses in tumor progression and how these responses in turn shape oncogenic progression. Lastly, we find evidence for the notion that the metabolic adaptability of tumors frequently frustrates therapeutic interventions. Keywords: Tumourigenesis, Tumour metabolism, Metabolic flexibility, Central carbon metabolism |
| Databáze: | OpenAIRE |
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