Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
| Autor: | Pilar Ciruela, Sonia Broner, Conchita Izquierdo, Roman Pallarés, Carmen Muñoz-Almagro, Sergi Hernández, Imma Grau, Angela Domínguez, Mireia Jané, P. Ciruela, C. Izquierdo, S. Broner, S. Hernández, M. Jané, C. Muñoz-Almagro, C. Esteva, M.F. de Sevilla, D. Henares, R. Pallarés, C. Ardanuy, I. Grau, F. Marco, N. Margall, A. González-Cuevas, A. Díaz, M.T. Martin, J. Llaberia, M. Curriu, C. Gallés, E. Capdevila, P. Gassiot, M. Martínez-Zurita, C. Martí, M. Morta, G. Sauca, A. Gassós, E. Sanfeliu, F. Ballester, I. Pujol, M. Olsina, X. Raga, F. Gómez-Bertomeu, M.O. Pérez-Moreno, A. Vilamala, M. Navarro, M. Ribelles, M. Garcia, E. Padilla, N. Prim, D. Fontanals, I. Sanfeliu, M.A. Benitez, E. Jou, C. Sanjosé, M. Giménez, M.D. Quesada, J.C. de la Fuente, A. Calderon, P.J. Ayala, L. Vega, J. Pérez-Jové, A. Blanco, C. Balado, I. Valle, M.T. Bastida, O. Gonzalez-Moreno, A. Ubanell, A. Fenoll, J. Yuste |
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| Přispěvatelé: | European Centre for Disease Prevention and Control (ECDC), Centro de Investigación Biomedica en Red - CIBER, [Ciruela P, Jané M] Agència de Salut Pública de Catalunya, Generalitat de Catalunya, Barcelona, Spain. CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. [Broner S, Izquierdo C, Hernández S] Agència de Salut Pública de Catalunya, Generalitat de Catalunya, Barcelona, Spain. [Pallarés R, Grau I] Hospital Universitari Bellvitge, Universitat de Barcelona (UB), L’Hospitalet, Spain. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. [Muñoz-Almagro C] CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. Hospital Universitari Sant Joan de Déu, Esplugues, Spain. Department of Medicine, Universitat Internacional de Catalunya (UIC), Sant Cugat del Vallès, Spain. [Domínguez A] CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. Departament de Medicina, Universitat de Barcelona (UB), Barcelona, Spain, Departament de Salut |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Bacteria::Firmicutes::Lactobacillales::Streptococcaceae::Streptococcus::Streptococcus pneumoniae [ORGANISMOS] PCV13 Infeccions per pneumococs Pneumococcal conjugate vaccine Persones grans Comorbidities Pneumococcal Vaccines 0302 clinical medicine Mezclas Complejas::Productos Biológicos::Vacunas::Vacunas Bacterianas::Vacunas Estreptocócicas::Vacunas Neumococicas [COMPUESTOS QUÍMICOS Y DROGAS] Case fatality rate 030212 general & internal medicine Vacunació Bacterias::Firmicutes::Lactobacillales::Streptococcaceae::Streptococcus::Streptococcus pneumoniae [ORGANISMOS] Aged 80 and over Pneumococs Mortality rate Incidence (epidemiology) Incidence Vaccination Complex Mixtures::Biological Products::Vaccines::Bacterial Vaccines::Streptococcal Vaccines::Pneumococcal Vaccines [CHEMICALS AND DRUGS] General Medicine Bacteria::Firmicutes::Lactobacillales::Streptococcaceae::Streptococcus::Streptococcus pneumoniae [ORGANISMS] Infectious Diseases Streptococcus pneumoniae Persons::Age Groups::Adult::Aged [NAMED GROUPS] Child Preschool Female Meningitis medicine.drug Microbiology (medical) medicine.medical_specialty 030106 microbiology Serogroup Pneumococcal Infections lcsh:Infectious and parasitic diseases 03 medical and health sciences Internal medicine medicine Mortalitat Adults Humans lcsh:RC109-216 Mortality personas::Grupos de Edad::adulto::anciano [DENOMINACIONES DE GRUPOS] Aged mezclas complejas::productos biológicos::vacunas::vacunas bacterianas::vacunas antiestreptocócicas::vacunas antineumocócicas [COMPUESTOS QUÍMICOS Y DROGAS] Vaccines Conjugate business.industry Cerebrospinal meningitis Meningitis cerebrospinal epidèmica Infant Odds ratio medicine.disease Confidence interval Vacuna antipneumocòccica IPD business |
| Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) Scientia Recercat. Dipósit de la Recerca de Catalunya instname International Journal of Infectious Diseases, Vol 86, Iss, Pp 122-130 (2019) Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | OBJECTIVES: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people ≥65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. METHODS: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. RESULTS: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age ≥85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and ≥1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). CONCLUSIONS: The incidence of IPD in people ≥65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, ≥1 high-risk condition, and PCV13 serotypes. This study was partially supported by SpIDnet (Assessing the impact of vaccination with conjugate vaccines on the epidemiology of invasive pneumococcal disease in Europe), a network funded by the European Centre for Disease Prevention and Control ( ECDC/2015/031 ); the Catalan Agency for the Management of Grants for University Research ( AGAUR Grant number 2017/SGR 1342 and 2017/SGR 0742 ); the Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública ( CIBERESP CB06/02/0076 and CB15/00067 ); and the Centro de Investigación Biomédica en Red de Enfermedades Respiratorias ( CIBERES CB06/06/0037 ). Sí |
| Databáze: | OpenAIRE |
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