Circulating leptin levels are associated with adiposity in survivors of childhood brain tumors
| Autor: | Donna L. Johnston, William Jennings, Shayna Zelcer, Adam Fleming, Carol Portwine, Shahrad Rod Rassekh, Brianna Empringham, Lehana Thabane, E. Danielle Sims, M. Constantine Samaan, Sarah Burrow |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Leptin Male Molecular biology lcsh:Medicine Adipose tissue Disease Type 2 diabetes Pediatrics 0302 clinical medicine Cancer Survivors Risk Factors lcsh:Science Child Adiposity education.field_of_study Multidisciplinary Brain Neoplasms Endocrine system and metabolic diseases 3. Good health Cardiovascular Diseases 030220 oncology & carcinogenesis Female Type 2 medicine.medical_specialty Adolescent Population Adipokine 030209 endocrinology & metabolism Predictive markers Article 03 medical and health sciences Predictive Value of Tests Internal medicine medicine Diabetes Mellitus Humans Risk factor education Waist-Height Ratio business.industry Waist-Hip Ratio lcsh:R Cancer medicine.disease Cross-Sectional Studies Early Diagnosis Diabetes Mellitus Type 2 lcsh:Q business Biomarkers |
| Zdroj: | Paediatrics Publications Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) |
| Popis: | Survivors of Childhood Brain Tumors (SCBT) are at a higher risk of developing cardiovascular disease and type 2 diabetes compared to the general population. Adiposity is an important risk factor for the development of these outcomes, and identifying biomarkers of adiposity may help the stratification of survivors based on their cardiovascular risk or allow for early screening and interventions to improve cardiometabolic outcomes. Leptin is an adipokine that positively correlates with the adipose mass in the general population and is a predictor of adverse cardiometabolic outcomes, yet its association with adiposity in SCBT has not been studied. The aim of this study was to determine if leptin levels are associated with the adipose mass in SCBT, and to define its predictors. This cross-sectional study included 74 SCBT (n = 32 females) with 126 non-cancer controls (n = 59 females). Total adiposity was measured using Bioelectrical Impendence Analysis (BIA) and central adiposity was measured using waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR). We used multivariable linear regression analysis to determine if leptin predicts adiposity in SCBT and adjusted for age, sex, puberty, and cancer status. Leptin correlated strongly with total (p |
| Databáze: | OpenAIRE |
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