Examination of potential novel biochemical factors in relation to prostate cancer incidence and mortality in UK Biobank
| Autor: | Naomi E. Allen, Georgina K. Fensom, Eleanor L. Watts, Ruth C. Travis, Mieke Van Hemelrijck, Timothy J. Key, Richard M. Martin, Colm Andrews, Aurora Perez-Cornago |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male Oncology Cancer Research Time Factors Prostate cancer 0302 clinical medicine Urea Prospective Studies 030212 general & internal medicine Vitamin D Incidence Hazard ratio Blood Proteins Middle Aged prostate cancer Biobank Cardiovascular Diseases 030220 oncology & carcinogenesis ICEP Cohort study Adult medicine.medical_specialty Regression dilution Predictive markers Article Phosphates 03 medical and health sciences Glycosuria Internal medicine Diabetes mellitus cohort study Biomarkers Tumor medicine Vitamin D and neurology Humans Aspartate Aminotransferases Cystatin C Aged business.industry Proportional hazards model biomarkers Prostatic Neoplasms prospective medicine.disease United Kingdom Risk factors business metabolism Follow-Up Studies |
| Zdroj: | British Journal of Cancer Perez-Cornago, A, Fensom, G K, Andrews, C, Watts, E L, Allen, N E, Martin, R M, Van Hemelrijck, M, Key, T J & Travis, R C 2020, ' Examination of potential novel biochemical factors in relation to prostate cancer incidence and mortality in UK Biobank ', British Journal of Cancer, vol. 123, pp. 1808–1817 (2020) . https://doi.org/10.1038/s41416-020-01081-3 |
| Popis: | Background Although prostate cancer is a leading cause of cancer death, its aetiology is not well understood. We aimed to identify novel biochemical factors for prostate cancer incidence and mortality in UK Biobank. Methods A range of cardiovascular, bone, joint, diabetes, renal and liver-related biomarkers were measured in baseline blood samples collected from up to 211,754 men at recruitment and in a subsample 5 years later. Participants were followed-up via linkage to health administrative datasets to identify prostate cancer cases. Hazard ratios (HRs) and 95% confidence intervals were calculated using multivariable-adjusted Cox regression corrected for regression dilution bias. Multiple testing was accounted for by using a false discovery rate controlling procedure. Results After an average follow-up of 6.9 years, 5763 prostate cancer cases and 331 prostate cancer deaths were ascertained. Prostate cancer incidence was positively associated with circulating vitamin D, urea and phosphate concentrations and inversely associated with glucose, total protein and aspartate aminotransferase. Phosphate and cystatin-C were the only biomarkers positively and inversely, respectively, associated with risk in analyses excluding the first 4 years of follow-up. There was little evidence of associations with prostate cancer death. Conclusion We found novel associations of several biomarkers with prostate cancer incidence. Future research will examine associations by tumour characteristics. |
| Databáze: | OpenAIRE |
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