Raised Lipoprotein(a) in Hypercholesterolaemic Black Students Compared to Age-Matched Whites in North and Souch Carolina
| Autor: | Kenneth A. Schneider, Gerd Assmann, Helmut Schulte, Siegfried Heyden, A. von Eckardstein |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Gerontology Adolescent Epidemiology South Carolina Hypercholesterolemia Population Black People White People chemistry.chemical_compound High-density lipoprotein Risk Factors North Carolina Humans Mass Screening Medicine Child education Health Education Stroke Belt Mass screening education.field_of_study biology business.industry Cholesterol Incidence General Medicine Lipoprotein(a) Lipids Cross-Sectional Studies chemistry Low-density lipoprotein biology.protein Female lipids (amino acids peptides and proteins) business Negroid Demography |
| Zdroj: | International Journal of Epidemiology. 23:301-306 |
| ISSN: | 1464-3685 0300-5771 |
| DOI: | 10.1093/ije/23.2.301 |
| Popis: | North and South Carolina are the states with the highest coronary death rates and also belong to the Stroke Belt of the US. From a Reflotron cholesterol screening in North and South Carolina schools, students with cholesterol levelsor = 4.66 mmol/l (or = 180 mg/dl) were tested for high density lipoprotein (HDL), low density lipoprotein (LDL) and lipoprotein(a) (Lp(a)).The 923 students aged 12-19 with mild hypercholesterolaemia represented one-third of the high school population, of whom 30% are black. Of the hypercholesterolaemic white students, 96% took the additional tests, of the hypercholesterolaemic black students, 88% responded. Lp(a) levels were determined by electroimmunodiffusion.Most important was a three-fold elevation of the geometric mean of Lp(a) values among blacks compared to whites: white males 9, white females 10, black males 25, black females 26 mg/dl, respectively, independent of age and sex. Relationships between Lp(a) and four other lipids/lipoproteins were examined and proved non-significant except for total cholesterol and LDL in black males and white females. While 70% of the white students displayed Lp(a) levels20 mg/dl, 65-70% of the black students showed Lp(a) levels20 mg/dl.Early identification of high Lp(a) levels may be of importance for two groups, (1) black females who have a 20% higher coronary heart disease mortality rate than white females in spite of significantly higher HDL levels; and (2) for black males and black females who have a prevalence of cerebrovascular disease twice as high as in whites. |
| Databáze: | OpenAIRE |
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