Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve
Autor: | Alison C. Lloyd, Francesca Florio, Robin D. S. Doddrell, Xin-Peng Dun, Maurizio D'Antonio, Sheridan L. Roberts, David Parkinson, Mark W. Onaitis, Louisa K. Drake, Angelo Quattrini, Thomas Mindos |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Proto-Oncogene Proteins c-jun Green Fluorescent Proteins Neural Conduction Schwann cell Mice Transgenic Inflammation Motor Activity Biology 03 medical and health sciences 0302 clinical medicine SOX2 Peripheral Nerve Injuries medicine Animals Peripheral Nerves Transgenes Axon Molecular Biology Early Growth Response Protein 2 Myelin Sheath beta Catenin Cell Proliferation Progenitor Macrophages SOXB1 Transcription Factors Recovery of Function Cadherins Rats Cell biology 030104 developmental biology medicine.anatomical_structure nervous system Peripheral nervous system Immunology Peripheral nerve injury Schwann Cells medicine.symptom Stem cell Biomarkers 030217 neurology & neurosurgery Research Article Developmental Biology |
Zdroj: | Development. |
ISSN: | 1477-9129 0950-1991 |
Popis: | Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both development and following peripheral nerve injury and repair. The Sox2 transcription factor is well known for its roles in the development and maintenance of progenitor and stem cell populations, but has also been proposed in vitro as a negative regulator of myelination in Schwann cells. We wished to test fully whether Sox2 regulates myelination in vivo and show here that, in mice, sustained Sox2 expression in vivo blocks myelination in the peripheral nerves and maintains Schwann cells in a proliferative non-differentiated state, which is also associated with increased inflammation within the nerve. The plasticity of Schwann cells allows them to re-myelinate regenerated axons following injury and we show that re-myelination is also blocked by Sox2 expression in Schwann cells. These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system. |
Databáze: | OpenAIRE |
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