Changes in renal tri-iodothyronine and thyroxine handling during fasting
| Autor: | Edgar J. Rolleman, E. P. Krenning, G. Hennemann, H. Van Toor, M. De Jong, C. H. H. Schoenmakers |
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| Přispěvatelé: | Internal Medicine, Clinical Chemistry, Radiology & Nuclear Medicine |
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Renal function Fatty Acids Nonesterified Biology Kidney Excretion chemistry.chemical_compound Endocrinology NEFA Internal medicine medicine Humans Kidney metabolism Fasting General Medicine Circadian Rhythm Uric Acid Thyroxine medicine.anatomical_structure chemistry Creatinine Renal physiology Triiodothyronine Uric acid Female Hormone |
| Zdroj: | European Journal of Endocrinology, 142, 125-130. Bioscientifica Ltd |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1420125 |
| Popis: | OBJECTIVE: Liver handling of thyroid hormones (TH) has been known to alter significantly during fasting. This study investigates whether renal handling of TH is also changed during fasting. METHODS: We measured urinary excretion rates and clearances of free tri-iodothyronine (T(3)) and free thyroxine (T(4)) in healthy subjects prior to and on the third day of fasting. RESULTS: During fasting, both mean T(3) and T(4) urinary excretion decreased significantly to a mean value of 42% of control. Also, total and free (F) serum T(3) concentrations declined significantly, but serum T(4) did not change. Both FT(3) and FT(4) clearance decreased significantly during fasting (62% and 42% of control). The fasting-induced decrease in uric acid clearance correlated well with the decrease in FT(3) clearance (r=0.94; P |
| Databáze: | OpenAIRE |
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