Effects of MK-801 on rat primary afferent neurons and fibers
| Autor: | Raymond E. Papka, Caroline M. Klein, Michelle M. Westermeyer, Ronald L. Shew, Eric W. Sherburn, Daniel L. McNeill, Brian K. Pilcher, J. Mark Galbraith |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Calcitonin Gene-Related Peptide Central nervous system Calcitonin gene-related peptide Biology Nerve Fibers Dorsal root ganglion Reference Values Ganglia Spinal Internal medicine medicine Animals Periaqueductal Gray Neurons Afferent Pathways Muscles General Neuroscience Glutamate receptor Rats Inbred Strains Spinal cord Rats Dizocilpine medicine.anatomical_structure Endocrinology Spinal Cord Calcitonin NMDA receptor Dizocilpine Maleate medicine.drug |
| Zdroj: | Brain Research Bulletin. 27:41-45 |
| ISSN: | 0361-9230 |
| Popis: | Recent evidence suggests that glutamate and its N-methyl-D-aspartate (NMDA) receptor may participate in regulating neurite morphology and peptide expression. A previous study from this laboratory showed that treatment with the NMDA receptor antagonist, MK-801, induced an apparent increase in the density of calcitonin gene-related peptide (CGRP)-immunoreactive primary afferent fibers in the dorsal spinal cord of the rat. The present study was undertaken to extend this work by: 1) quantifying the MK-801-induced increase in CGRP immunostaining in the dorsal grey commissure/medial dorsal horn region and 2) examining the effect of MK-801 on the number of CGRP-immunoreactive primary afferent cell bodies in lumbar dorsal root ganglia. Following 7 days of MK-801 treatment, a significant increase (p less than 0.001) in CGRP immunostaining was observed in the dorsal grey commissure/medial dorsal horn. However, after MK-801 treatment, no significant difference was noted in the numbers of CGRP-immunoreactive primary afferent cell bodies in dorsal root ganglia. These data suggest that MK-801 produces significant alterations in the intraspinal projection of CGRP-immunoreactive fibers without inducing immunocytochemically detectable CGRP within a new population of primary afferent neurons. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|