Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals
| Autor: | Sulantha Mathotaarachchi, Henrik Zetterberg, Pedro Rosa Neto, Michael Schöll, Aurélie Labbe, Eduardo R. Zimmer, Nicholas J. Ashton, Andrea Lessa Benedet, Serge Gauthier, Tharick A. Pascoal, Antoine Leuzy, Mira Chamoun, Min S. Kang, Kaj Blennow, Melissa Savard, Joseph Therriault |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Neurofilament light Neurology Disease lcsh:Geriatrics lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Internal medicine medicine Neurodegeneration lcsh:Neurology. Diseases of the nervous system 030304 developmental biology Fluorodeoxyglucose 0303 health sciences business.industry Fdg uptake Alzheimer's disease medicine.disease Special Section: Blood-Based Biomarkers for Alzheimer's Disease and Related Dementias. (Editor: Henrik Zetterberg) Psychiatry and Mental health lcsh:RC952-954.6 Endocrinology Blood PET Hypometabolism Longitudinal Biomarker (medicine) Neurology (clinical) [18F]FDG business 030217 neurology & neurosurgery Biomarkers medicine.drug |
| Zdroj: | Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 679-689 (2019) |
| ISSN: | 2352-8729 |
| Popis: | Introduction Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However, there are limited reports of how longitudinal NfL relates to imaging biomarkers. We herein investigated the relationship between blood NfL and brain metabolism in AD. Methods Voxelwise regression models tested the cross-sectional association between [18F]fluorodeoxyglucose ([18F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Linear mixed models were also used to test the longitudinal association between NfL and [18F]FDG in amyloid positive (Aβ+) and negative (Aβ−) subjects. Results Higher concentrations of plasma and cerebrospinal fluid NfL were associated with reduced [18F]FDG uptake in correspondent brain regions. In Aβ+ participants, NfL associates with hypometabolism in AD-vulnerable regions. Longitudinal changes in the association [18F]FDG-NfL were confined to cognitively impaired Aβ+ individuals. Discussion These findings indicate that plasma NfL is a proxy for neurodegeneration in AD-related regions in Aβ+ subjects. Highlights • Plasma and CSF neurofilament light show similar pattern of association with [18F]FDG. • In Aβ+ group, brain hypometabolism associates with NfL in Alzheimer's disease signature regions. • The association [18F]fluorodeoxyglucose-plasma NfL increases over 24 months in Aβ+ patients. |
| Databáze: | OpenAIRE |
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