Cerebellar excitatory and inhibitory amino acid receptors in multiple system atrophy
| Autor: | J. B. Penney, Sharin Y. Sakurai, Anne B. Young, Roger L. Albin, Richard H. Price, Ronald J. Polinsky |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Cerebellum medicine.medical_specialty Purkinje cell Shy-Drager Syndrome Kainate receptor Biology Inhibitory postsynaptic potential Receptors N-Methyl-D-Aspartate Radioligand Assay Basal Ganglia Diseases Internal medicine medicine Humans Receptors Amino Acid Aged GABAA receptor Middle Aged Granule cell Receptors GABA-A Dentate nucleus medicine.anatomical_structure Endocrinology nervous system Olivopontocerebellar Atrophies Autoradiography Neurology (clinical) Amino acid binding |
| Zdroj: | Neurology. 43(7) |
| ISSN: | 0028-3878 |
| Popis: | We studied excitatory and inhibitory amino acid binding sites autoradiographically in control and multiple system atrophy (MSA) cerebella. Within the dentate nucleus (DN) of MSA specimens, we found a significant increase in the level of GABAA, benzodiazepine, and metabotropic binding sites compared with controls. In the granule cell layer, kainate, JV-methyl-D-aspartate, and GABAA binding sites were all decreased significantly in MSA specimens compared with controls. In the molecular layer of MSA cerebellum, a-amino-3-hydroxy-5-methylisoxazole-4-propionate binding sites were decreased significantly compared with controls. Cerebellar cortical binding site decreases are likely due to Purkinje and granule cell loss. The increase of binding site levels in DN of MSA specimens may represent receptor up-regulation reflecting loss of descending inhibitory Purkinje cell and ascending excitatory afferents to the DN. |
| Databáze: | OpenAIRE |
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