Evaluation of a Novel Artificial Tear in the Prevention and Treatment of Dry Eye in an Animal Model
| Autor: | Bing Xiao, Wei Chen, Haixia Liu, Yujing She, Peter A. Simmons, Jinyang Li, Joseph G. Vehige, Huihui Lu |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Conjunctiva medicine.medical_treatment Dry Eye Syndromes Lubricant Eye Drops Cornea Mice chemistry.chemical_compound Ophthalmology Hyaluronic acid medicine Animals Pharmacology (medical) Hyaluronic Acid Saline Fluorescent Dyes Pharmacology business.industry Original Articles eye diseases Surgery Mice Inbred C57BL Disease Models Animal Regimen Artificial tears Treatment Outcome medicine.anatomical_structure chemistry Carboxymethylcellulose Sodium Female Fluorescein Goblet Cells sense organs business |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics |
| ISSN: | 1557-7732 1080-7683 |
| Popis: | Purpose: To evaluate effects of a novel multi-ingredient artificial tear formulation containing carboxymethylcellulose (CMC) and hyaluronic acid (HA) in a murine dry eye model. Methods: Dry eye was induced in mice (C57BL/6) using an intelligently controlled environmental system (ICES). CMC+HA (Optive Fusion™), CMC-only (Refresh Tears®), and HA-only (Hycosan®) artificial tears and control phosphate-buffered saline (PBS) were administered 4 times daily and compared with no treatment (n = 64 eyes per group). During regimen 1 (prevention regimen), mice were administered artificial tears or PBS for 14 days (starting day 0) while they were exposed to ICES, and assessed on days 0 and 14. During regimen 2 (treatment regimen), mice exposed to ICES for 14 days with no intervention were administered artificial tears or PBS for 14 days (starting day 14) while continuing exposure to ICES, and assessed on days 0, 14, and 28. Corneal fluorescein staining and conjunctival goblet cell density were measured. Results: Artificial tear-treated mice had significantly better outcomes than control groups on corneal staining and goblet cell density (P |
| Databáze: | OpenAIRE |
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