Familial aggregation of atrial fibrillation: a study in Danish twins
| Autor: | Jesper Hastrup Svendsen, Kaare Christensen, Ingrid E. Christophersen, Lasse Steen Ravn, S. Haunsoe, Aksel Skytthe, Esben Budtz-Joergensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Biometry Denmark Dizygotic twin Concordance Monozygotic twin Article Risk Factors Physiology (medical) Internal medicine Atrial Fibrillation Prevalence Twins Dizygotic Humans Medicine Registries Sibling Aged Proportional Hazards Models Aged 80 and over Family Health Models Genetic business.industry Incidence Hazard ratio Family aggregation Twins Monozygotic Middle Aged Heritability Twin study Female Cardiology and Cardiovascular Medicine business Demography |
| Zdroj: | Christophersen, I E, Ravn, L S, Budtz-Joergensen, E, Skytthe, A, Haunsoe, S, Svendsen, J H & Christensen, K 2009, ' Familial aggregation of atrial fibrillation: a study in Danish twins ', Circulation. Arrhythmia and electrophysiology, vol. 2, no. 4, pp. 378-383 . https://doi.org/10.1161/CIRCEP.108.786665 |
| Popis: | Background— Heritability may play a role in nonfamilial atrial fibrillation (AF). We hypothesized that a monozygotic (MZ) twin whose co-twin was diagnosed with AF would have an increased risk of the disease compared with a dizygotic (DZ) twin in the same situation. Methods and Results— A sample of 1137 same-sex twin pairs (356 MZ and 781 DZ pairs) in which one or both members were diagnosed with AF were identified in The Danish Twin Registry. Concordance rates were twice as high for MZ pairs than for DZ pairs regardless of sex (22.0% versus 11.6%, P Conclusions— All the analyses of twin similarities in the present study indicate that genetic factors play a substantial role in the risk of AF for both sexes. The recurrence risk for co-twins (12% to 22%) is clinically relevant and suggests that co-twins of AF-affected twins belong to a high-risk group for AF. |
| Databáze: | OpenAIRE |
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