Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide
| Autor: | D. Mohammad Nejad, J Soleimani Rad, Leila Roshangar, Ramin Salimnejad |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Cyclophosphamide Urology medicine.medical_treatment media_common.quotation_subject Fertility Biology medicine.disease_cause Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Mice Endocrinology Internal medicine Testis medicine Animals Antineoplastic Agents Alkylating media_common Epididymis Chemotherapy Mice Inbred BALB C In vitro fertilisation Sperm Count General Medicine Sperm Spermatozoa Ghrelin Oxidative Stress 030104 developmental biology chemistry Models Animal Sperm Motility Lipid Peroxidation Oxidative stress Injections Intraperitoneal medicine.drug |
| Zdroj: | Andrologia. 50(2) |
| ISSN: | 1439-0272 |
| Popis: | Summary Cyclophosphamide is a drug used for chemotherapy and as an immune-suppressive in the organ transplantation. Despite its many clinical implications in the treatment of cancers, this drug has toxic effects on the reproductive system. This study aimed to evaluate the effect of ghrelin against the damages caused by cyclophosphamide. In this experimental study, 40 male mice were randomly divided into four groups: (i) control; (ii) cyclophosphamide; (iii) cyclophosphamide + ghrelin; and (iv) ghrelin. Cyclophosphamide (100 mg/kg body weight), once a week, and ghrelin (80 μg/kg body weight), daily, were administered intraperitoneally for 5 weeks. After 5 weeks, the epididymides were removed and the lipid peroxidation, total antioxidant capacity and sperm parameters were examined. The fertility rate was evaluated by performance in vitro fertilisation. In the mice exposed to cyclophosphamide, the number of spermatozoa and viability, as well as total antioxidant capacity, decreased significantly (p |
| Databáze: | OpenAIRE |
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