Potential Use of Chemoprotectants against the Toxic Effects of Cyanotoxins: A Review

Autor: Ana I. Prieto, María Puerto, Alexandre Campos, Silvia Pichardo, Ana M. Cameán, Remedios Guzmán-Guillén, Ángeles Jos, Vitor Vasconcelos, Daniel Gutiérrez-Praena
Přispěvatelé: CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
silymarin
Health
Toxicology and Mutagenesis
aurantiin
sulforaphane
heart failure
Transport inhibitors
melatonin
Review
Pharmacology
Toxicology
medicine.disease_cause
alpha tocopherol
rifampicin
chemistry.chemical_compound
intoxication
thioctic acid
Cyclosporin a
cylindrospermopsin
oxidative stress
Chemoprotection
Antioxidant substances
glutathione
amifostine
cysteine
chemistry.chemical_classification
antioxidant substances
Cyanobacteria Toxins
cyanotoxin
unclassified drug
Environmental chemistry
Toxicity
ascorbic acid
liver injury
epigallocatechin gallate
microcystin
Microcystins
Bacterial Toxins
chemoprotection
Microcystin
Biology
Protective Agents
03 medical and health sciences
transport inhibitors
Alkaloids
acetylcysteine
medicine
Chemoprotectants
bacterial toxin
osmotic agent
Animals
Humans
14. Life underwater
human
Uracil
liver hemorrhage
nonhuman
tumor promotion
carnitine
Cyanotoxin
Ascorbic acid
cyclosporin A
030104 developmental biology
cytochalasin
chemistry
Cylindrospermopsin
Oxidative stress
trolox C
Zdroj: Toxins
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
ISSN: 2072-6651
Popis: Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant compounds are the most extensively studied, probably because it is well known that oxidative stress is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin mixtures and the concomitant use of chemoprotectants, should be considered. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This work was supported by the the Ministerio de Economía y Competitividad of Spain (AGL2015-64558-R, MINECO/FEDER, UE), by the FCT Project—UID/Multi/04423/2013, and by the Structured Program of R&D&I INNOVMAR—Innovation and Sustainability in the Management and Exploitation of Marine Resources (reference NORTE-01-0145-FEDER-000035, Research Line NOVELMAR), funded by the Northern Regional Operational Program (NORTE2020) through the European Regional Development Fund (ERDF). Alexandre Campos work is supported by a post-doctoral grant (SFRH/BPD/103683/2014) from Foundation for Science and Technology (FCT, Lisbon, Portugal).
Databáze: OpenAIRE
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