Rapid viral response and treatment outcome in genotype 2 and 3 chronic hepatitis C: comparison between two HCV RNA quantitation methods
| Autor: | Ola Weiland, Tony Carlsson, Anne Quist |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Time Factors Genotype viruses Hepacivirus Hepatitis C virus Interferon alpha-2 medicine.disease_cause Antiviral Agents Sensitivity and Specificity Virus Polyethylene Glycols chemistry.chemical_compound Flaviviridae Pegylated interferon Virology Ribavirin TaqMan medicine Humans biology business.industry Interferon-alpha Hepatitis C Chronic Middle Aged Viral Load biology.organism_classification Recombinant Proteins Treatment Outcome Infectious Diseases chemistry RNA Viral Female Viral disease business medicine.drug |
| Zdroj: | Journal of Medical Virology. 80:803-807 |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.21133 |
| Popis: | Fifty consecutive patients with genotype 2 or 3 chronic hepatitis C were treated with peg-IFN alfa-2a 135 µg weekly and ribavirin (11 mg/kg body weight) daily during 24 weeks. Rapid viral response treatment week 4, end-of-treatment response, and sustained viral response were analyzed by two different HCV RNA quantitation methods, the Cobas Amplicor Monitor test and the TaqMan test with a sensitivity of 600 and 15 IU/ml, respectively. The TaqMan test differentiated patients with rapid viral response finally achieving sustained viral response better. Hence, patients with and without rapid viral response as tested by the TaqMan test finally achieved sustained viral response in 97% (32/33) versus in 75% (12/16), P |
| Databáze: | OpenAIRE |
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