Effect of Low-Density Lipoprotein Apheresis on Circulating Endothelial Progenitor Cells in Familial Hypercholesterolemia
| Autor: | Francesco Resta, Roberto Ria, Giacoma De Tullio, Laura Capuzzimati, P. Coratelli, Angelo Vacca, Alfonso Ramunni, Porzia Dambra, Gianpaolo Russi, Paola Brescia |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Cell Count Familial hypercholesterolemia Hyperlipoproteinemia Type II chemistry.chemical_compound Internal medicine medicine Humans Progenitor cell Low density lipoprotein apheresis business.industry Cholesterol Stem Cells Endothelial Cells Cholesterol LDL Hematology General Medicine Middle Aged medicine.disease Hematopoietic Stem Cell Mobilization Lipoproteins LDL Endothelial stem cell Endocrinology Apheresis chemistry Nephrology Case-Control Studies Low-density lipoprotein Blood Component Removal Female lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors business Lipoprotein |
| Zdroj: | Blood Purification. 29:383-389 |
| ISSN: | 1421-9735 0253-5068 |
| DOI: | 10.1159/000314650 |
| Popis: | Background: Long-term treatment with low-density lipoprotein (LDL) apheresis (LA) has been shown to reduce the incidence of cardiovascular events in patients affected by familial hypercholesterolemia (FH). Data from experimental studies suggest that circulating endothelial progenitor cells (EPCs) can repair the vascular lesions caused by atherosclerosis. Since a reduction of these cells has been demonstrated to predict atherosclerosis progression, the aim of this study was to verify whether LA can increase the percentage of EPCs. Methods: In 15 patients affected by FH periodically treated with LA, the percentage of EPCs was determined before and after performing LA, and compared with the values of 15 control subjects and 15 hypercholesterolemic patients treated with statins. Results: Significant differences were found in FH patients between the pre-apheresis percentages of CD34+/KDR+, defined as EPCs by a wide consensus of opinion, and the values found 24 h after the procedures (0.00868 ± 0.003 vs. 0.01009 ± 0.002%, p < 0.005). Instead, the percentages of CD34+/KDR+/CD133+, considered as an immature subset of EPCs, remained substantially unchanged. However, a significant reduction in the percentage of EPCs was observed in both patient groups as compared to the controls, at all the assessment times. Conclusion: In the short-term LA seems to stimulate mobilization of CD34+/KDR+ cells. Hypercholesterolemic patients show a lower percentage of EPCs than controls. There were no differences in the EPCs percentages between the 2 patients groups, despite the fact that LDL cholesterol levels were higher in the group undergoing LA. |
| Databáze: | OpenAIRE |
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