Interaction of chloroquine and carrageenan
| Autor: | Karl F. Swingle |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
animal structures animal diseases Ph dependent Carrageenan Biochemistry Glycosaminoglycan chemistry.chemical_compound Saline solutions Chloroquine medicine Animals Edema Drug Interactions Pharmacology Chromatography Foot Chemistry Hydrogen-Ion Concentration respiratory system In vitro carbohydrates (lipids) Spectrophotometry Ultraviolet Swelling medicine.symptom medicine.drug |
| Zdroj: | Biochemical Pharmacology. 23:1669-1674 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(74)90393-1 |
| Popis: | Amounts of chloroquine from 0.25 to 5.0 mg, when mixed with a carrageenan suspension and injected into the rat's paw, inhibit the swelling normally induced by the injection of carrageenan alone. This effect appears to be explainable in terms of a physicochemical interaction between chloroquine and carrageenan. The interaction can be demonstrated in vitro by determining the extinction of chloroquine-carrageenan mixtures at 400 nm. The reaction is pH dependent. The chloroquine-carrageenan complexes are soluble in saline solutions. When amounts of chloroquine and carrageenan are reacted which do not result in a detectable precipitate, the u.v. absorbancy curve of chloroquine is quenched. The amount of chloroquine recovered from the chloroquine-carrageenan complexes is linearly related to the amount of chloroquine added until the excess (by weight) of chloroquine to carrageenan exceeds about 3. It is suggested that the interaction between mucopolysaccharides and chloroquine may be of importance for the accumulation of antirheumatic concentrations of chloroquine in connective tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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