Gated Myocardial Perfusion Scintigraphy in Children with Sickle Cell Anemia: Correlation with Echocardiography

Autor: Olgu Hallioglu, A. Erdogan, S. Balci, Selma Unal, E. Ceylan Gunay, Derya Citirik
Rok vydání: 2011
Předmět:
Male
Microbiology (medical)
medicine.medical_specialty
Iron Overload
Adolescent
Heart Ventricles
Vasodilator Agents
Immunology
Anemia
Sickle Cell
Scintigraphy
Iron Chelating Agents
Benzoates
Correlation
Ventricular Dysfunction
Left
Internal medicine
medicine
Humans
Hydroxyurea
Immunology and Allergy
Radiology
Nuclear Medicine and imaging
Prospective Studies
Prospective cohort study
Child
Ejection fraction
medicine.diagnostic_test
business.industry
Myocardial Perfusion Imaging
Transfusion Reaction
Stroke Volume
Dipyridamole
Triazoles
medicine.disease
Sickle cell anemia
Acute chest syndrome
Chelation Therapy
Deferasirox
medicine.anatomical_structure
Ventricle
Cardiology
Female
business
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
Perfusion
Dilatation
Pathologic
Echocardiography
Stress
Zdroj: Revista Española de Medicina Nuclear (English Edition). 30:354-359
ISSN: 1578-200X
DOI: 10.1016/j.remngl.2011.02.008
Popis: The heart is one of the organs affected by sickle cell anemia (SCA). This prospective study has aimed to evaluate myocardial perfusion and left ventricle (LV) function in children with SCA by gated myocardial perfusion scintigraphy (G-MPS) and to compare the results with echocardiographic parameters.Forty-three patients with SCA were evaluated by G-MPS and echocardiography. Myocardial perfusion and motion with thickening function were analyzed both visually and quantitatively. End-diastolic (EDV), end-systolic volumes (ESV), ejection fraction (EF), lung-to-heart (L/H) ratio were also calculated.None of the patients showed stress perfusion impairment in G-MPS. LV dilatation in 15 patients was observed both by G-MPS and echocardiography. EF values were within normal limits. Correlation between EF values calculated by two methods was not statistically significant. However, LV dilatation detected by both methods and EDV-ESV values in G-MPS were correlated to end-diastolic and end-systolic diameters calculated in echocardiography (p0.05). M-Mode echocardiography revealed higher myocardial performance index (LV-MPI) in patients with LV dilatation. There was also a significant relationship between LV dilatation and frequent blood transfusions (5/years) and acute chest syndrome (p0.05).Myocardial perfusion impairment in children with SCA is not frequently observed. Thus, performing the scintigraphy only in patients with cardiac symptoms should be considered. Since EF values of the children with SCA are not deteriorated in early stages, LV-MPI and LV dilatation should be considered as a significant parameter other than EF or perfusion data.
Databáze: OpenAIRE
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