Transcriptional regulation from the cell surface: conformational changes in the transmembrane protein FecR lead to altered transcription of the ferric citrate transport genes in Escherichia coli
| Autor: | K Wriedt, Volkmar Braun, Annemarie Angerer |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
inorganic chemicals
Transcription Genetic Protein Conformation medicine.medical_treatment Mutant Receptors Cell Surface Sigma Factor Biology medicine.disease_cause Microbiology Ferric Compounds Transcription (biology) Transcriptional regulation medicine Escherichia coli RNA Messenger Molecular Biology Gene Protease Escherichia coli Proteins Membrane Transport Proteins Gene Expression Regulation Bacterial Transmembrane protein Biochemistry Cytoplasm Genes Bacterial bacteria Carrier Proteins Bacterial Outer Membrane Proteins Research Article |
| Zdroj: | Journal of bacteriology. 177(11) |
| ISSN: | 0021-9193 |
| Popis: | Ferric citrate induces the ferric citrate transport system in Escherichia coli without being taken up into cells. The cytoplasmic transmembrane protein FecR, required for the response to ferric citrate, was found to be cleaved by a cellular protease. FecR protein produced by fecR mutants impaired or constitutive in fecA transcription was protease resistant, indicating that conformational changes affect proper functioning of FecR. |
| Databáze: | OpenAIRE |
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