Primary cutaneous carcinosarcoma: clinical, histological, and immunohistochemical analysis of eight cases
| Autor: | Julián Conejo-Mir, Fernando Garcia-Souto, José Juan Pereyra-Rodríguez, Rocío Cabrera‐Pérez, Jerónimo Escudero-Ordoñez, Antonio José Durán-Romero |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Antigens Differentiation Myelomonocytic Dermatology Metastasis Desmin 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Carcinosarcoma Patient age Antigens CD medicine Humans Head and neck Retrospective Studies Aged 80 and over business.industry Membrane Proteins Retrospective cohort study Matrix Attachment Region Binding Proteins Tertiary care hospital Middle Aged medicine.disease Immunohistochemistry Actins 030220 oncology & carcinogenesis alpha 1-Antitrypsin Female Myogenin Neprilysin Keratin-3 Neoplasm Recurrence Local business Keratin-1 Transcription Factors |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) |
| Popis: | [Background] Cutaneous carcinosarcoma is a rare biphasic tumor comprising malignant epithelial and heterologous mesenchymal elements. Data on the clinical and histopathologic characteristics of this tumor are scarce. The objective of this study was to describe the clinicopathologic and immunohistochemical features of cutaneous carcinosarcoma. [Methods] A descriptive retrospective study was conducted in a tertiary care hospital from Spain. We reviewed the records of eight patients with cutaneous carcinosarcoma who were diagnosed from 2009 to 2019. [Results] The mean patient age at diagnosis was 72.13 years (range 44–91 years), and there was a male predilection (6 cases). The most common site of cutaneous carcinosarcoma was the head and neck (5 cases). Carcinosarcomas demonstrated variable histopathological and immunohistochemical features. Follow‐up was available for 7–8 patients. There were two cases of local recurrence and one case of metastasis. Two patients died from the tumor during the entire follow‐up. [Conclusions] Although the number of cases in this study was limited, our results provide valuable insight into the clinical, histopathologic, and immunohistochemical characteristics of primary cutaneous carcinosarcoma. |
| Databáze: | OpenAIRE |
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