Heart rate-dependent variability of cardiac events in type 2 congenital long-QT syndrome
| Autor: | Shiro Kamakura, Takeru Makiyama, Tomoko Sakaguchi, Kenichiro Yamagata, Hisaki Makimoto, Yuka Mizusawa, Seiko Ohno, Wataru Shimizu, Yoshihiro Miyamoto, Iori Nagaoka, Hideki Itoh, Minoru Horie |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Adolescent Adrenergic beta-Antagonists Torsades de pointes Logistic regression QT interval Disease-Free Survival Syncope Young Adult Basal (phylogenetics) Heart Rate Risk Factors Torsades de Pointes Physiology (medical) Internal medicine Heart rate Humans Medicine cardiovascular diseases Age of Onset Risk factor Aged Retrospective Studies Aged 80 and over business.industry Middle Aged medicine.disease Heart Arrest Long QT Syndrome Anesthesia Mutation Ventricular Fibrillation Ventricular fibrillation cardiovascular system Cardiology Population study Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Europace. 12:1623-1629 |
| ISSN: | 1532-2092 1099-5129 |
| DOI: | 10.1093/europace/euq342 |
| Popis: | Aims We aimed to examine the validity of heart rate (HR) at rest before β-blocker therapy as a risk factor influencing cardiac events (ventricular fibrillation, torsades de pointes, or syncope) in long QT type 2 (LQT2) patients. Methods and results In 110 genetically confirmed LQT2 patients (45 probands), we examined the significance of variables [HR at rest, corrected QT (QTc), female gender, age of the first cardiac event, mutation site] as a risk factor for cardiac events. We also evaluated frequency of cardiac events in four groups classified by the combination of basal HR and QTc with cutoff values of 60 b.p.m. and 500 ms to estimate if these two electrocardiographic parameters in combination could be a good predictor of outcome (mean follow-up period: 50 ± 39 months). Logistic regression analysis revealed three predictors: HR |
| Databáze: | OpenAIRE |
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