| Popis: |
The metabolism of the stereomeric cyclic glycerol acetals of [1-14C] hexadecanal was studied in myelinating rat brain. It was found that the four isomers, cis- and trans-2-pentadecyl-5-hydroxy-l,3-dioxanes and cis- and trans-2-pentadecyl-4-hydroxymethyl-1,3-dioxolanes, were utilized by the tissue at different rates. The acetals were primarily metabolized via a ring-opening mechanism leading to palmitic acid, some of which was subsequently elongated–desaturated. Only the five-membered ring isomers were incorporated as intact acetals into both neutral and polar brain lipids. |
