Design, characterization and in vitro evaluation of antifungal polymeric films

Autor: Claudio J. Salomon, Marina del Valle Soazo, Daniel Andres Real, A. Frattini, Alicia G. Luque, Marisa S. Biasoli, Maria V. Martinez, Darío Leonardi, Alejandro Cesar Olivieri
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Thermogravimetric analysis
Antifungal Agents
Polymers
THERMOGRAVIMETRIC ANALYSIS
Físico-Química
Ciencia de los Polímeros
Electroquímica
Drug Evaluation
Preclinical
Pharmaceutical Science
Polyethylene glycol
Aquatic Science
In Vitro Techniques
Microscopy
Atomic Force
Chitosan
chemistry.chemical_compound
DRUG DELIVERY SYSTEMS
Candida krusei
Drug Discovery
Spectroscopy
Fourier Transform Infrared
Organic chemistry
Fourier transform infrared spectroscopy
Ecology
Evolution
Behavior and Systematics
chemistry.chemical_classification
Ecology
biology
IN-VITRO MODELS
Ciencias Químicas
General Medicine
Polymer
biology.organism_classification
Thermogravimetry
chemistry
Econazole Nitrate
Drug Design
Microscopy
Electron
Scanning
ANTI-FUNGAL ACTIVITY
INFRARED SPECTROSCOPY
Agronomy and Crop Science
CIENCIAS NATURALES Y EXACTAS
Nuclear chemistry
Research Article
DOI: 10.1208/s12249-012-9894-0
Popis: The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers–ECN and CH–CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed. Fil: Real, Daniel Andres. Universidad Nacional de Rosario; Argentina Fil: Martinez, Maria V.. Universidad Nacional de Rosario; Argentina Fil: Frattini, Agustin Lujan. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina Fil: Soazo, Marina del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina Fil: Luque, Alicia G.. Universidad Nacional de Rosario; Argentina Fil: Biasoli, Marisa S.. Universidad Nacional de Rosario; Argentina Fil: Salomon, Claudio Javier. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina Fil: Olivieri, Alejandro Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina Fil: Leonardi, Darío. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Databáze: OpenAIRE
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