Papillary serous carcinoma of the peritoneum: analysis of clonality of peritoneal tumors
| Autor: | Toshikazu Hashimoto, Yoshihide Fujiyama, Masato Wakabayashi, Masahito Ebina, Masako Nishimura, Tadao Bamba, Junsuke Shibata, Hisao Ueyama |
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| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Ovary Gene mutation Biology Polymerase Chain Reaction law.invention Peritoneum Surgical oncology law medicine Humans Point Mutation Codon Cystadenocarcinoma Peritoneal Neoplasms Polymerase chain reaction Aged Gastroenterology Sequence Analysis DNA Genes p53 medicine.disease Immunohistochemistry Primary Neoplasm medicine.anatomical_structure Cystadenocarcinoma Papillary Cancer research Female Tumor Suppressor Protein p53 |
| Zdroj: | Journal of Gastroenterology. 35:540-547 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/s005350070078 |
| Popis: | Papillary serous carcinoma of the peritoneum (PSCP) is a primary neoplasm of peritoneal origin, and is histologically difficult to differentiate from papillary serous carcinoma of the ovary (PSCO). PSCP is frequently accompanied by many peritoneal tumors, and has been managed as a disseminated disease. In previous reports, however, the clonality of the tumors has not been fully discussed. Recently, the significant roles of the p53 and BRCA1 genes in PSCP have been reported. In this study, we investigated immunohistochemical staining for p53 proteins, and investigated p53 gene mutations, using DNA sequencing analysis, to clarify the clonality of PSCP tumors. Immunohistochemically, all the tumor samples demonstrated nuclear overexpression of p53 proteins, and the DNA sequencing analysis of the p53 gene showed diverse point mutations at codons 167 and 192 in two of four anatomically different tumors. In conclusion, the possibility of polyclonality of PSCP tumors is suggested. |
| Databáze: | OpenAIRE |
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