Herpes Simplex Virus Encephalitis in Suckling Mice: Ultrastructural Studies of Virus Replication
Autor: | Jerome Schwartz, Teresita S. Elizan |
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Rok vydání: | 1975 |
Předmět: |
Cytoplasm
viruses Biology Cytoplasmic Granules Virus Replication medicine.disease_cause Microtubules Pathology and Forensic Medicine Mice Cellular and Molecular Neuroscience Tissue culture Microtubule medicine Animals Simplexvirus Nuclear membrane Cell Nucleus Brain General Medicine medicine.disease Virology Microscopy Electron medicine.anatomical_structure Herpes simplex virus Neurology Viral replication Ultrastructure Encephalitis Neurology (clinical) Subcellular Fractions |
Zdroj: | Journal of Neuropathology & Experimental Neurology. 34:359-368 |
ISSN: | 1554-6578 0022-3069 |
Popis: | Ultrastructural studies concerning the replication and release of a neuro-adapted strain of herpes simplex virus were carried out on acutely encephalitic mice. It was found that envelopment of nucleocapsid particles at the nuclear membrane of brain cells was inefficient, resulting in accumulation of un-enveloped nucleocapsids in the cell cytoplasm. These nucleocapsids were associated with arrays of microtubules within cytoplasmic processes. Enveloped particles were rarely present in tissue spaces. Those that were seen appeared to be in a state of disintegration. This replication process of herpes simplex virus in the murine encephalitis model differs from that observed in tissue culture cells. The implications of these differences are discussed. |
Databáze: | OpenAIRE |
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