DNA methylation: its contribution to systemic lupus erythematosus
| Autor: | Kazuhiko Kaneda, Iwao Sekigawa, Hideoki Ogawa, Hiroshi Kaneko, Hitoshi Ogasawara, Mikiko Kawasaki, Yoshinari Takasaki |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Transcription Genetic Disease General Biochemistry Genetics and Molecular Biology Epigenesis Genetic Pathogenesis Mice chemistry.chemical_compound immune system diseases Internal medicine medicine Animals Humans Lupus Erythematosus Systemic Epigenetics skin and connective tissue diseases Hematology business.industry Human endogenous retrovirus Endogenous Retroviruses Toll-Like Receptors General Medicine Methylation DNA Methylation chemistry Immunology DNA methylation CpG Islands business DNA |
| Zdroj: | Clinical and Experimental Medicine. 6:99-106 |
| ISSN: | 1591-9528 1591-8890 |
| DOI: | 10.1007/s10238-006-0103-x |
| Popis: | Recent studies on epigenetics, including the methylation of DNA and the enzymes regulating methylation, seem likely to contribute to understanding the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). In fact, the relationship between DNA methylation and SLE has long been the subject of investigation. To obtain a deeper understanding of the role of DNA methylation in the onset of SLE, we reviewed the findings reported in the literature and our own data about DNA methylation and SLE. Various studies have indicated the possible importance of DNA methylation, especially hypomethylation, in the aetiology of SLE. Epigenetic studies may provide clues for elucidating the pathogenesis of SLE and for developing new strategies to treat this disease. |
| Databáze: | OpenAIRE |
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