An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels
| Autor: | Sumanta Samanta, Vignesh K. Rangasami, Vijay Singh Parihar, Oommen P. Oommen, N. Arul Murugan, Oommen P. Varghese |
|---|---|
| Přispěvatelé: | Tampere University, BioMediTech |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Polymers and Plastics
Kinetics Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry chemistry.chemical_compound Dopamine Hyaluronic acid medicine Polymerkemi Organic chemistry Gallic acid Catechol 318 Medical biotechnology Chemistry Organic Chemistry 021001 nanoscience & nanotechnology Polymer Chemistry 0104 chemical sciences 216 Materials engineering Self-healing hydrogels Adhesive 0210 nano-technology Conjugate medicine.drug |
| Popis: | We present here a new insight into the chemical reactivity and bioactivity of dopamine (DA) and gallic acid (GA) and their hyaluronic acid (HA) conjugates. Our data suggest that HA-GA scaffolds are superior to HA-DA, with higher oxidation kinetics, improved tissue adhesive properties, and radical scavenging ability with a lower pro-inflammatory response. This journal is publishedVersion |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|