Immunological Response of Mice to Members of the Autochthonous Intestinal Microflora
| Autor: | Adrian Lee, M. C. Foo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1972 |
| Předmět: |
Rodent
Immunology Guinea Pigs Biology Microbiology Cecum Feces Mice Antigen biology.animal Agglutination Tests Pseudomonas Intestine Small medicine Animals Bacteroides Germ-Free Life Proteus mirabilis Immunization Schedule Sheep Complement Fixation Tests Stomach Immunity food and beverages Opsonin Proteins biology.organism_classification Complement fixation test Proteus Antibodies Bacterial Antibody opsonization Bacterial vaccine Intestines Lactobacillus Infectious Diseases medicine.anatomical_structure Antibody Formation Bacterial Vaccines Pseudomonas aeruginosa biology.protein Parasitology Rabbits Antibody |
| Popis: | Based on agglutination, complement fixation, bactericidal, and opsonization tests, it is evident that suspensions of a Bacteroides sp. isolated from the mouse intestine and given by parenteral routes do not initiate antibody formation in mice. Rats also respond poorly to the antigenic stimulus. In contrast, suspensions of other bacterial species isolated from the rodent intestine are highly immunogenic. Furthermore, high titers of antibody are produced in rabbits, guinea pigs, and sheep after parenteral injection of the Bacteroides suspensions. Marked differences in the absolute and relative numbers of Bacteroides in the intestinal contents of rodents and the latter three animal species have been demonstrated. It is proposed that the immunological unresponsiveness of rodents to this organism is related to its existence as a member of the autochthonous microflora in these animals. |
| Databáze: | OpenAIRE |
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