Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction
| Autor: | Yuji Akiyama, Eiji Imamura, Yuji Shiga, Yuki Hayashi, Hayato Matsushima, Tomohisa Nezu, Shinichi Wakabayashi, Hirofumi Maruyama, Fumiyuki Yamasaki, Masahiro Nakamori, Kazuo Awai, Tomohiko Ohshita, Shiro Aoki, Teppei Kamimura, Naohisa Hosomi, Keisuke Tachiyama, Naoto Kinoshita, Hiroki Ueno |
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| Rok vydání: | 2021 |
| Předmět: |
Brain Infarction
Male medicine.medical_specialty Proton Magnetic Resonance Spectroscopy Infarction Lenticulostriate artery Choline 03 medical and health sciences Disability Evaluation 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans In patient cardiovascular diseases Aged Aged 80 and over Pyramidal tracts business.industry Basal Ganglia Cerebrovascular Disease Rehabilitation Middle Aged medicine.disease Creatine medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Coronal plane Ischemic stroke Logistic analysis Infarct volume Cardiology Disease Progression Surgery Female Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 30(6) |
| ISSN: | 1532-8511 |
| Popis: | Objectives The present study aimed to examine the effectiveness of proton magnetic resonance spectroscopy (1HMRS) in determining the progression of neurological symptoms resulting in acute ischemic stroke in patients with lenticulostriate artery (LSA) infarction. Materials and Methods 1HMRS was performed within 72 h after neurological symptom onset. Voxel of interest was placed in tissue that included the pyramidal tract and identified diffusion weighted echo planar spin-echo sequence (DWI) coronal images. Infarct volume in DWI was calculated using the ABC/2 method. 1HMRS data (tNAA, tCr, Glx, tCho, and Ins) were analyzed using LCModel. Progressive neurological symptoms were defined as an increase of 1 or more in the NIHSS score. Patients who underwent 1HMRS after progressive neurological symptoms were excluded. Results In total, 77 patients were enrolled. Of these, 19 patients had progressive neurological symptoms. The patients with progressive neurological symptoms were significantly more likely to be female and had higher tCho/tCr values, higher rates of axial slices ≥ 3 slices on DWI, higher infarct volume on DWI, higher maximum diameter of infarction of axial slice on DWI, and higher SBP on admission compared to those without. Multivariable logistic analysis revealed that higher tCho/tCr values were independently associated with progressive neurological symptoms after adjusting for age, sex, and initial DWI infarct volume (tCho/tCr per 0.01 increase, OR 1.26, 95% CI 1.03–1.52, P = 0.022). Conclusions Increased tCho/tCr score were associated with progressive neurological symptoms in patients with LSA ischemic stroke. Quantitative evaluation of 1HMRS parameters may be useful for predicting the progression of neurological symptoms. |
| Databáze: | OpenAIRE |
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